Table of contents

1. Introduction to Biochemistry4h 34m
2. Water3h 23m
3. Amino Acids8h 10m
4. Protein Structure10h 4m
5. Protein Techniques14h 5m
6. Enzymes and Enzyme Kinetics13h 38m
7. Enzyme Inhibition and Regulation 8h 42m
8. Protein Function 9h 41m
9. Carbohydrates7h 49m
10. Lipids5h 49m
11. Biological Membranes and Transport 6h 37m
12. Biosignaling9h 45m
Review 1: Nucleic Acids, Lipids, & Membranes2h 47m
Review 2: Biosignaling, Glycolysis, Gluconeogenesis, & PP-Pathway3h 12m
Review 3: Pyruvate & Fatty Acid Oxidation, Citric Acid Cycle, & Glycogen Metabolism2h 26m
Review 4: Amino Acid Oxidation, Oxidative Phosphorylation, & Photophosphorylation1h 48m

6. Enzymes and Enzyme Kinetics

Enzyme-Substrate Complex

Biochemistry

6. Enzymes and Enzyme Kinetics

Enzyme-Substrate Complex

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Multiple Choice

According to the induced fit hypothesis of enzyme catalysis, which of the following best describes the interaction between an enzyme and its substrate?

The substrate is permanently altered to fit the enzyme's active site.

The enzyme changes its conformation upon substrate binding to better fit the substrate.

The enzyme and substrate fit together perfectly without any conformational change.

The enzyme binds to the substrate only through covalent bonds.

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Verified step by step guidance

Understand the induced fit hypothesis: This model suggests that enzymes are flexible and can change their shape or conformation upon binding to a substrate. This conformational change enhances the enzyme's ability to catalyze the reaction.

Analyze the options provided: Evaluate each statement to determine which aligns with the induced fit hypothesis. For example, the idea that the enzyme changes its conformation upon substrate binding is central to this hypothesis.

Eliminate incorrect options: Discard options that contradict the induced fit hypothesis, such as the substrate being permanently altered to fit the enzyme's active site or the enzyme binding only through covalent bonds.

Focus on the correct description: The induced fit hypothesis emphasizes that the enzyme adapts its shape to better fit the substrate, rather than the substrate being permanently altered or the enzyme-substrate interaction being rigid.

Select the correct answer: Based on the analysis, choose the option that states 'The enzyme changes its conformation upon substrate binding to better fit the substrate,' as this best describes the induced fit hypothesis.