Table of contents

1. Introduction to Biochemistry4h 34m
2. Water3h 23m
3. Amino Acids8h 10m
4. Protein Structure10h 4m
5. Protein Techniques14h 5m
6. Enzymes and Enzyme Kinetics13h 38m
7. Enzyme Inhibition and Regulation 8h 42m
8. Protein Function 9h 41m
9. Carbohydrates7h 49m
10. Lipids5h 49m
11. Biological Membranes and Transport 6h 37m
12. Biosignaling9h 45m
Review 1: Nucleic Acids, Lipids, & Membranes2h 47m
Review 2: Biosignaling, Glycolysis, Gluconeogenesis, & PP-Pathway3h 12m
Review 3: Pyruvate & Fatty Acid Oxidation, Citric Acid Cycle, & Glycogen Metabolism2h 26m
Review 4: Amino Acid Oxidation, Oxidative Phosphorylation, & Photophosphorylation1h 48m

6. Enzymes and Enzyme Kinetics

Enzyme-Substrate Complex

Biochemistry

6. Enzymes and Enzyme Kinetics

Enzyme-Substrate Complex

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Multiple Choice

How do the enzyme and substrate "fit" together during the formation of the enzyme-substrate complex?

The substrate binds randomly to any part of the enzyme's surface.

The substrate fits into the enzyme's active site like a key fits into a lock (lock-and-key model).

The enzyme completely engulfs the substrate without any structural change.

The enzyme and substrate both undergo conformational changes to achieve a complementary fit (induced fit model).

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Verified step by step guidance

Understand the concept of enzyme-substrate interaction: Enzymes are biological catalysts that speed up chemical reactions by lowering the activation energy. Substrates are the molecules upon which enzymes act.

Learn about the induced fit model: Unlike the lock-and-key model, the induced fit model suggests that both the enzyme and substrate undergo conformational changes to achieve a complementary fit. This dynamic interaction ensures specificity and optimal catalytic activity.

Identify the active site: The active site is the specific region of the enzyme where the substrate binds. It is shaped to interact with the substrate but may adjust its structure during binding.

Explore conformational changes: When the substrate approaches the enzyme, the enzyme's active site adjusts its shape to better accommodate the substrate. Similarly, the substrate may also change slightly to fit into the active site.

Understand the importance of the induced fit model: This model explains how enzymes can be flexible and adapt to different substrates, enhancing their ability to catalyze reactions efficiently and with high specificity.