Table of contents

1. Introduction to Biochemistry4h 34m
2. Water3h 23m
3. Amino Acids8h 10m
4. Protein Structure10h 4m
5. Protein Techniques14h 5m
6. Enzymes and Enzyme Kinetics13h 38m
7. Enzyme Inhibition and Regulation 8h 42m
8. Protein Function 9h 41m
9. Carbohydrates7h 49m
10. Lipids5h 49m
11. Biological Membranes and Transport 6h 37m
12. Biosignaling9h 45m
Review 1: Nucleic Acids, Lipids, & Membranes2h 47m
Review 2: Biosignaling, Glycolysis, Gluconeogenesis, & PP-Pathway3h 12m
Review 3: Pyruvate & Fatty Acid Oxidation, Citric Acid Cycle, & Glycogen Metabolism2h 26m
Review 4: Amino Acid Oxidation, Oxidative Phosphorylation, & Photophosphorylation1h 48m

6. Enzymes and Enzyme Kinetics

Enzyme-Substrate Complex

Biochemistry

6. Enzymes and Enzyme Kinetics

Enzyme-Substrate Complex

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Multiple Choice

Which of the following statements best describes the interaction between an enzyme's active site and its substrate?

The substrate and active site must have identical shapes for binding to occur.

The substrate can bind to any region of the enzyme, regardless of shape.

The substrate and active site bind only if they have no structural similarity.

The substrate and active site must have complementary shapes for binding to occur.

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Verified step by step guidance

Understand the concept of enzyme-substrate interaction: Enzymes are biological catalysts that speed up chemical reactions by lowering the activation energy. The active site of an enzyme is a specific region where the substrate binds to form an enzyme-substrate complex.

Learn about the 'lock and key' model: This model suggests that the active site of the enzyme and the substrate have complementary shapes, much like a key fitting into a lock. This structural complementarity ensures specificity in the binding process.

Explore the 'induced fit' model: While the 'lock and key' model emphasizes static complementarity, the 'induced fit' model explains that the active site can undergo slight conformational changes to better fit the substrate upon binding, enhancing the interaction.

Clarify misconceptions: The substrate does not bind to any random region of the enzyme; it specifically binds to the active site. Additionally, the substrate and active site must have structural similarity or complementarity, not identical shapes, for effective binding.

Conclude with the correct statement: The substrate and active site must have complementary shapes for binding to occur. This complementarity ensures the enzyme's specificity and efficiency in catalyzing the reaction.