Table of contents

1. Introduction to Biochemistry4h 34m
2. Water3h 23m
3. Amino Acids8h 10m
4. Protein Structure10h 4m
5. Protein Techniques14h 5m
6. Enzymes and Enzyme Kinetics13h 38m
7. Enzyme Inhibition and Regulation 8h 42m
8. Protein Function 9h 41m
9. Carbohydrates7h 49m
10. Lipids5h 49m
11. Biological Membranes and Transport 6h 37m
12. Biosignaling9h 45m
Review 1: Nucleic Acids, Lipids, & Membranes2h 47m
Review 2: Biosignaling, Glycolysis, Gluconeogenesis, & PP-Pathway3h 12m
Review 3: Pyruvate & Fatty Acid Oxidation, Citric Acid Cycle, & Glycogen Metabolism2h 26m
Review 4: Amino Acid Oxidation, Oxidative Phosphorylation, & Photophosphorylation1h 48m

7. Enzyme Inhibition and Regulation

Enzyme Inhibition

Biochemistry

7. Enzyme Inhibition and Regulation

Enzyme Inhibition

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Multiple Choice

Which enzyme prevents supercoiling of DNA during replication by introducing transient breaks in the DNA strands?

Ligase

Polymerase

Topoisomerase

Helicase

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Verified step by step guidance

Understand the problem: DNA supercoiling occurs during replication as the DNA strands are unwound by helicase. This creates tension in the DNA molecule, which needs to be relieved to allow replication to proceed smoothly.

Identify the role of each enzyme listed: Ligase seals nicks in the DNA backbone, Polymerase synthesizes new DNA strands, Helicase unwinds the DNA strands, and Topoisomerase introduces transient breaks to relieve supercoiling.

Focus on the function of Topoisomerase: Topoisomerase works by cutting one or both strands of the DNA, allowing the molecule to relax and then resealing the breaks. This prevents the accumulation of supercoils during replication.

Relate the enzyme's function to the problem: Since the question asks for the enzyme that prevents supercoiling, Topoisomerase is the correct answer because it directly addresses the issue of tension caused by unwinding.

Conclude the reasoning: Based on the functions of the enzymes provided, Topoisomerase is the enzyme responsible for preventing supercoiling during DNA replication by introducing transient breaks in the DNA strands.