Table of contents

1. Introduction to Biochemistry4h 34m
2. Water3h 23m
3. Amino Acids8h 10m
4. Protein Structure10h 4m
5. Protein Techniques14h 5m
6. Enzymes and Enzyme Kinetics13h 38m
7. Enzyme Inhibition and Regulation 8h 42m
8. Protein Function 9h 41m
9. Carbohydrates7h 49m
10. Lipids5h 49m
11. Biological Membranes and Transport 6h 37m
12. Biosignaling9h 45m
Review 1: Nucleic Acids, Lipids, & Membranes2h 47m
Review 2: Biosignaling, Glycolysis, Gluconeogenesis, & PP-Pathway3h 12m
Review 3: Pyruvate & Fatty Acid Oxidation, Citric Acid Cycle, & Glycogen Metabolism2h 26m
Review 4: Amino Acid Oxidation, Oxidative Phosphorylation, & Photophosphorylation1h 48m

7. Enzyme Inhibition and Regulation

Enzyme Inhibition

Biochemistry

7. Enzyme Inhibition and Regulation

Enzyme Inhibition

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Multiple Choice

Dephosphorylation and which of the following are the two basic mechanisms that can inactivate receptor tyrosine kinases?

Allosteric activation

Increased ligand binding

Receptor internalization

Covalent modification by acetylation

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Verified step by step guidance

Step 1: Understand the role of receptor tyrosine kinases (RTKs). RTKs are enzymes that play a critical role in cell signaling by phosphorylating tyrosine residues on target proteins. Their activation is typically initiated by ligand binding, leading to downstream signaling cascades.

Step 2: Recognize the mechanisms of RTK inactivation. Dephosphorylation is one mechanism, where phosphate groups are removed from tyrosine residues, effectively halting the signaling process. The second mechanism involves receptor internalization, where the receptor is removed from the cell surface and transported into the cell, preventing further interaction with ligands.

Step 3: Eliminate incorrect options. Allosteric activation refers to the enhancement of enzyme activity, which is the opposite of inactivation. Increased ligand binding would also enhance RTK activity rather than inactivate it. Covalent modification by acetylation is not a common mechanism for RTK inactivation.

Step 4: Focus on receptor internalization. This process involves the receptor being endocytosed into the cell, often leading to degradation or recycling, which effectively stops its signaling activity.

Step 5: Conclude that the two basic mechanisms for RTK inactivation are dephosphorylation and receptor internalization, as these directly halt the signaling pathways initiated by RTKs.