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Multiple Choice
Which of the following best describes the relationship between glucose and glycogen in glycogen metabolism?
A
Glycogen is broken down to form glucose through glycolysis.
B
Glycogen is synthesized from amino acids rather than glucose.
C
Glucose is converted directly into fatty acids before forming glycogen.
D
Glucose is stored as glycogen through the process of glycogenesis.
Verified step by step guidance
1
Understand the key terms: Glucose is a simple sugar and a primary energy source for cells, while glycogen is a storage form of glucose found in liver and muscle cells.
Learn the process of glycogenesis: Glycogenesis is the biochemical pathway through which glucose is converted into glycogen for storage. This occurs when the body has excess glucose and energy needs are low.
Explore the enzymatic steps in glycogenesis: Glucose is first phosphorylated to glucose-6-phosphate by hexokinase or glucokinase. Then, it is converted to glucose-1-phosphate by phosphoglucomutase. Next, glucose-1-phosphate reacts with UTP (uridine triphosphate) to form UDP-glucose, catalyzed by UDP-glucose pyrophosphorylase.
Understand glycogen synthase's role: Glycogen synthase is the key enzyme that adds glucose units from UDP-glucose to the growing glycogen chain, forming α-1,4-glycosidic bonds. Branching enzyme introduces α-1,6-glycosidic bonds to create a branched structure.
Review the relationship: Glucose is stored as glycogen through glycogenesis, ensuring energy is available for later use during periods of fasting or increased energy demand.