Multiple Choice
Which option best corresponds with the effect of CO2 on hemoglobin's O2-binding?
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8. Protein Function
Hemoglobin Carbonation & Protonation
Multiple Choice
Choose all of the following molecules that, when bound, trigger hemoglobin's transition from T to R state.
A
CO2
B
CO
C
O2
D
2,3-Bisphosphoglycerate
E
H+
Verified step by step guidance1
Understand the T (tense) and R (relaxed) states of hemoglobin: Hemoglobin can exist in two main conformations, the T state, which has a lower affinity for oxygen, and the R state, which has a higher affinity for oxygen.
Identify the role of oxygen (O2) in hemoglobin's transition: Oxygen binding to hemoglobin stabilizes the R state, facilitating the transition from the T state to the R state.
Consider the effect of other molecules: CO2, H+, and 2,3-Bisphosphoglycerate (2,3-BPG) are known to stabilize the T state, thus promoting oxygen release rather than binding.
Recognize the role of carbon monoxide (CO): CO binds to hemoglobin with a high affinity, but it does not trigger the T to R transition; instead, it prevents oxygen from binding effectively.
Conclude that O2 is the molecule that, when bound, triggers the transition from the T state to the R state in hemoglobin, enhancing its oxygen-binding capacity.
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