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Multiple Choice
In oxidative phosphorylation, what is the primary role of NADH and FADH2?
A
They transport protons across the inner mitochondrial membrane through specific channels.
B
They act as final electron acceptors by reacting with oxygen to form water.
C
They donate high-energy electrons to the electron transport chain, helping drive proton pumping across the inner mitochondrial membrane.
D
They directly catalyze the phosphorylation of ADP to ATP by binding and hydrolyzing ATP.
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Verified step by step guidance
1
Understand the role of NADH and FADH2 in cellular respiration, specifically in oxidative phosphorylation, which occurs in the mitochondria.
Recognize that NADH and FADH2 are electron carriers that have been reduced during earlier stages of metabolism (glycolysis, pyruvate oxidation, and the citric acid cycle).
Know that the primary function of NADH and FADH2 is to donate high-energy electrons to the electron transport chain (ETC), a series of protein complexes embedded in the inner mitochondrial membrane.
These donated electrons move through the ETC, and their energy is used to pump protons (H+) from the mitochondrial matrix to the intermembrane space, creating a proton gradient.
This proton gradient then drives ATP synthesis by ATP synthase, but NADH and FADH2 themselves do not directly catalyze ATP formation or act as final electron acceptors.