Table of contents

1. Introduction to Biochemistry4h 34m
2. Water3h 23m
3. Amino Acids8h 10m
4. Protein Structure10h 4m
5. Protein Techniques14h 5m
6. Enzymes and Enzyme Kinetics13h 38m
7. Enzyme Inhibition and Regulation 8h 42m
8. Protein Function 9h 41m
9. Carbohydrates7h 49m
10. Lipids5h 49m
11. Biological Membranes and Transport 6h 37m
12. Biosignaling9h 45m
Review 1: Nucleic Acids, Lipids, & Membranes2h 47m
Review 2: Biosignaling, Glycolysis, Gluconeogenesis, & PP-Pathway3h 12m
Review 3: Pyruvate & Fatty Acid Oxidation, Citric Acid Cycle, & Glycogen Metabolism2h 26m
Review 4: Amino Acid Oxidation, Oxidative Phosphorylation, & Photophosphorylation1h 48m

6. Enzymes and Enzyme Kinetics

Enzyme-Substrate Complex

Biochemistry

6. Enzymes and Enzyme Kinetics

Enzyme-Substrate Complex

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Multiple Choice

Which of the following best describes the induced fit model of enzyme-substrate interaction?

The substrate must have a perfect complementary shape to the enzyme's active site before binding.

The enzyme changes its shape slightly to better fit the substrate upon binding.

The enzyme and substrate form a covalent bond that permanently alters the enzyme.

The enzyme's active site is rigid and does not change shape during substrate binding.

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Verified step by step guidance

Step 1: Begin by understanding the concept of the induced fit model. The induced fit model describes how enzymes interact with substrates. Unlike the lock-and-key model, where the substrate must perfectly match the enzyme's active site, the induced fit model suggests that the enzyme's active site is flexible and adjusts its shape slightly upon substrate binding.

Step 2: Analyze the options provided in the problem. The first option suggests that the substrate must have a perfect complementary shape to the enzyme's active site before binding, which aligns with the lock-and-key model, not the induced fit model.

Step 3: Evaluate the second option, which states that the enzyme changes its shape slightly to better fit the substrate upon binding. This aligns with the induced fit model, as it emphasizes the flexibility of the enzyme's active site to accommodate the substrate.

Step 4: Consider the third option, which mentions the formation of a covalent bond that permanently alters the enzyme. This is incorrect because enzyme-substrate interactions are typically non-covalent and reversible, allowing the enzyme to catalyze multiple reactions.

Step 5: Review the fourth option, which claims that the enzyme's active site is rigid and does not change shape during substrate binding. This contradicts the induced fit model, as the model specifically highlights the dynamic nature of the enzyme's active site.