Multiple Choice
In the pentose phosphate pathway, which enzyme catalyzes the first committed step, resulting in the production of 6-phosphoglucono-δ-lactone from glucose-6-phosphate?
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Review 2: Biosignaling, Glycolysis, Gluconeogenesis, & PP-Pathway
Pentose Phosphate Pathway
Multiple Choice
The advantage of the pentose phosphate pathway is that it produces all of the following except:
A
Ribose-5-phosphate
B
NADPH
C
Erythrose-4-phosphate
D
ATP
Verified step by step guidance1
Step 1: Begin by understanding the pentose phosphate pathway (PPP). The PPP is a metabolic pathway parallel to glycolysis that primarily serves two functions: generating NADPH for biosynthetic reactions and producing ribose-5-phosphate for nucleotide synthesis.
Step 2: Identify the key products of the pentose phosphate pathway. These include NADPH, ribose-5-phosphate, and intermediates such as erythrose-4-phosphate, which are involved in various biosynthetic processes.
Step 3: Recall that ATP is not produced in the pentose phosphate pathway. Unlike glycolysis or the citric acid cycle, the PPP does not involve substrate-level phosphorylation or oxidative phosphorylation to generate ATP.
Step 4: Compare the listed molecules (Ribose-5-phosphate, NADPH, Erythrose-4-phosphate, and ATP) with the known products of the pentose phosphate pathway. Exclude ATP as it is not a product of this pathway.
Step 5: Conclude that the advantage of the pentose phosphate pathway lies in its ability to produce NADPH, ribose-5-phosphate, and erythrose-4-phosphate, but not ATP.
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