Multiple Choice
True or false: Increasing [S] in the presence of an uncompetitive inhibitor will lower the inhibition constant (KI).
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7. Enzyme Inhibition and Regulation
Uncompetitive Inhibition
Multiple Choice
What is the effect of an uncompetitive inhibitor on the equilibrium between free enzyme & the ES-complex?
A
A shift to the right due to decreased [ES].
B
A shift to the left due to decreased [ES].
C
A shift to the right due to increased [ES].
D
A shift to the left due to increased [ES].
Verified step by step guidance1
Understand the role of an uncompetitive inhibitor: It binds only to the enzyme-substrate (ES) complex, not to the free enzyme.
Recognize that uncompetitive inhibition decreases the concentration of the ES complex by forming an ESI complex, which cannot proceed to form product.
Consider the effect on equilibrium: The binding of the inhibitor to the ES complex reduces the amount of ES available, shifting the equilibrium to form more ES from free enzyme and substrate.
Analyze the options: A shift to the right indicates an increase in ES, while a shift to the left indicates a decrease in ES.
Conclude that the presence of an uncompetitive inhibitor shifts the equilibrium to the right due to decreased [ES], as the system compensates by forming more ES.
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