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Multiple Choice
During DNA replication (part of the central dogma), what enzyme unwinds the parental DNA double helix at the replication fork?
A
Primase
B
DNA polymerase III
C
DNA helicase
D
DNA ligase
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Verified step by step guidance
1
Understand the role of each enzyme listed in the context of DNA replication.
Recall that DNA helicase is the enzyme responsible for unwinding the parental DNA double helix at the replication fork, separating the two strands to allow replication to occur.
Recognize that primase synthesizes RNA primers needed to start DNA synthesis, but does not unwind DNA.
Know that DNA polymerase III is the main enzyme that adds nucleotides to the growing DNA strand, but it requires the DNA strands to be separated first.
Remember that DNA ligase joins Okazaki fragments on the lagging strand but does not participate in unwinding the DNA.