Multiple Choice
Which of the following represents the best order of signal transduction for the β-adrenergic receptor?
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12. Biosignaling
Stimulatory Adenylate Cyclase GPCR Signaling
Multiple Choice
Which of the following reactions does the enzyme adenylate cyclase catalyze?
A
cATP to cAMP.
B
GTP to cGMP.
C
ATP to cADP.
D
cGMP to GTP.
E
ATP to cAMP.
Verified step by step guidance1
Understand the role of adenylate cyclase: Adenylate cyclase is an enzyme that catalyzes the conversion of ATP (adenosine triphosphate) to cAMP (cyclic adenosine monophosphate). This reaction is crucial in many biological signaling pathways.
Identify the substrates and products: In the context of adenylate cyclase, the substrate is ATP, and the product is cAMP. This conversion involves the removal of two phosphate groups from ATP and the formation of a cyclic structure in the remaining phosphate group.
Analyze the given options: Review each reaction option to determine which one involves the conversion of ATP to cAMP. The options provided are: cATP to cAMP, GTP to cGMP, ATP to cADP, and cGMP to GTP.
Eliminate incorrect options: cATP to cAMP is incorrect because adenylate cyclase does not use cATP as a substrate. GTP to cGMP and cGMP to GTP are incorrect because they involve guanine nucleotides, not adenine nucleotides. ATP to cADP is incorrect because adenylate cyclase does not produce cADP.
Select the correct reaction: The correct reaction catalyzed by adenylate cyclase is ATP to cAMP, as it matches the enzyme's known function of converting ATP into cyclic AMP.
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