Multiple Choice
Insulin binds to a receptor that:
I. Is coupled to a G protein.
II. Possesses tyrosine kinase activity.
III. Possesses serine/threonine phosphatase activity.
IV. Interacts with the adapter protein IRS-1.
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12. Biosignaling
Insulin Receptor
Multiple Choice
The insulin receptor is an example of a _______:
A
G-protein coupled receptor.
B
Receptor tyrosine kinase.
C
Receptor tyrosine phosphatase.
D
Membrane channel protein.
E
Receptor threonine kinase.
Verified step by step guidance1
Understand the role of the insulin receptor in cellular signaling. It is involved in the regulation of glucose uptake and metabolism.
Identify the main types of receptors involved in signal transduction: G-protein coupled receptors, receptor tyrosine kinases, receptor tyrosine phosphatases, membrane channel proteins, and receptor threonine kinases.
Recall that receptor tyrosine kinases (RTKs) are a class of receptors that, upon binding to their ligand (such as insulin), undergo autophosphorylation on tyrosine residues.
Recognize that the insulin receptor is a well-known example of a receptor tyrosine kinase, which is activated by insulin binding and initiates a cascade of downstream signaling events.
Conclude that the correct classification for the insulin receptor is a receptor tyrosine kinase, based on its mechanism of action and role in signal transduction.
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