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What happens to proteins that are marked by ubiquitination?
How does phosphorylation transition an enzyme between inactive and active states?
Analyze how the storage of zymogens prevents damage to cellular proteins.
In the context of pharmacology, why is it important to consider the dissociation rate constant (kd) of a drug when designing a new therapeutic agent?
What does the protein ligand dissociation equilibrium constant (Kd) indicate about ligand concentration?
On a saturation curve, what does a lower Kd value indicate about a protein's affinity for a ligand?
What would be the consequence if hemoglobin lacked allosteric regulation?
What structural characteristic of the heme prosthetic group is similar to a UFO?
How does hemoglobin's oxygen binding curve change with varying partial pressures of oxygen, and what are the physiological implications?
What is the benefit of using a Hill plot in analyzing protein ligand binding data?
If a Hill plot shows an x-intercept at log[O2] = 1.5, what is the KD value for this protein?
What is the role of carbonic anhydrase in red blood cells, and how does it affect hemoglobin's function?
What is the role of hemoglobin's subunits in the formation of carbaminohemoglobin?
How does CO2 produced by cellular respiration affect hemoglobin in tissues?
What does BPG stand for and what is its primary role in hemoglobin's oxygen binding activity?
If two heterozygous individuals for the sickle cell trait have a child, what is the probability that the child will have sickle cell anemia?
How does prior knowledge of enzyme catalysis help in understanding chymotrypsin's mechanism?
During the nucleophilic attack in the acylation phase, what role does histidine 57 play?
Which form of glycogen phosphorylase is more active in the liver and why?
How does high blood glucose concentration affect liver Glycogen Phosphorylase a?
How do antibodies contribute to humoral immunity?
In sandwich ELISA, what is the sequence of components added to the well?
A vesicle is observed being transported along a microtubule towards the positively charged end. Which motor protein is responsible?
During muscle contraction, what role does the sarcoplasmic reticulum play?
What is the sliding filament model?