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Multiple Choice
In the absence of oxygen, cells need a way to regenerate which compound following glycolysis?
A
Glucose
B
FADH$_2$
C
NAD$^+$
D
ATP
Verified step by step guidance
1
Understand the context: Glycolysis is the process by which glucose is broken down into pyruvate, producing ATP and NADH. In the absence of oxygen, cells cannot proceed with aerobic respiration, which normally regenerates NAD$^+$ by transferring electrons to the electron transport chain.
Recognize the problem: Without oxygen, NAD$^+$ must be regenerated through an alternative pathway to allow glycolysis to continue. This is crucial because NAD$^+$ is required as an electron acceptor during glycolysis.
Learn the solution: Cells use fermentation to regenerate NAD$^+$. In lactic acid fermentation (common in animal cells), pyruvate is reduced to lactate, and NADH is oxidized back to NAD$^+$. In alcoholic fermentation (common in yeast), pyruvate is converted to ethanol and carbon dioxide, regenerating NAD$^+$ in the process.
Understand why NAD$^+$ is the correct answer: NAD$^+$ is essential for glycolysis to continue producing ATP in anaerobic conditions. Without NAD$^+$, glycolysis would halt, and the cell would be unable to generate energy.
Review the incorrect options: Glucose is the substrate for glycolysis, not the compound being regenerated. FADH$_2$ is involved in the electron transport chain, which requires oxygen. ATP is produced during glycolysis but is not regenerated in this context.