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Multiple Choice
Which of the following is an example of a receptor tyrosine kinase?
A
G-protein coupled receptor (GPCR)
B
Steroid hormone receptor
C
Ion channel receptor
D
Epidermal Growth Factor Receptor (EGFR)
Verified step by step guidance
1
Understand the role of receptor tyrosine kinases (RTKs): RTKs are a class of cell surface receptors that, upon binding with a ligand, activate their intrinsic kinase activity, leading to the phosphorylation of tyrosine residues on certain proteins.
Identify the characteristics of a receptor tyrosine kinase: RTKs typically have an extracellular ligand-binding domain, a single transmembrane helix, and an intracellular domain with tyrosine kinase activity.
Compare the given options with the characteristics of RTKs: G-protein coupled receptors (GPCRs) are not RTKs; they work through a different mechanism involving G-proteins. Steroid hormone receptors are intracellular and not membrane-bound, and ion channel receptors facilitate ion flow across membranes.
Recognize the Epidermal Growth Factor Receptor (EGFR) as a classic example of a receptor tyrosine kinase: EGFR is a well-known RTK that, upon binding with its ligand (epidermal growth factor), undergoes dimerization and autophosphorylation, initiating a cascade of downstream signaling pathways.
Conclude that the Epidermal Growth Factor Receptor (EGFR) fits the description of a receptor tyrosine kinase, unlike the other options provided.