Begin by understanding the basic structural differences between eukaryotic and prokaryotic cells. Eukaryotic cells have a defined nucleus where their genetic material is enclosed, whereas prokaryotic cells do not have a nucleus; their genetic material is found in a nucleoid region.
Next, consider the DNA structure in both cell types. Eukaryotic cells typically have linear DNA organized into chromosomes within the nucleus, while prokaryotic cells have circular DNA that is not enclosed in a nucleus.
Examine the size difference between the two cell types. Eukaryotic cells are generally larger and more complex than prokaryotic cells, which are smaller and simpler.
Identify the presence of membrane-bound organelles. Eukaryotic cells contain various membrane-bound organelles such as mitochondria, endoplasmic reticulum, and Golgi apparatus, which are absent in prokaryotic cells.
Summarize the key differences: Eukaryotic cells have a nucleus and membrane-bound organelles, are generally larger, and have linear DNA, whereas prokaryotic cells lack a nucleus and membrane-bound organelles, are smaller, and have circular DNA.