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Multiple Choice
Which is the main event of translation termination?
A
The ribosome binds to the mRNA at the start codon.
B
A stop codon is recognized by a release factor, leading to the release of the polypeptide chain from the ribosome.
C
A peptide bond is formed between two adjacent amino acids.
D
A tRNA carrying methionine binds to the P site of the ribosome.
Verified step by step guidance
1
Understand the process of translation termination: Translation is the final step of protein synthesis, where the ribosome reads the mRNA sequence to assemble a polypeptide chain. Termination occurs when the ribosome encounters a stop codon on the mRNA.
Identify the role of stop codons: Stop codons (UAA, UAG, UGA) do not code for any amino acid. Instead, they signal the end of translation by attracting release factors.
Learn about release factors: Release factors are proteins that recognize stop codons and bind to the ribosome. This binding triggers the hydrolysis of the bond between the polypeptide chain and the tRNA in the P site.
Understand the release of the polypeptide chain: Once the release factor is bound, the polypeptide chain is detached from the ribosome, completing the synthesis of the protein.
Recognize the disassembly of the ribosome: After the polypeptide chain is released, the ribosome subunits, mRNA, and tRNA dissociate, allowing the ribosome to be reused for another round of translation.