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Multiple Choice
Which of the following is unlikely to affect bone remodeling?
A
Calcitonin signaling
B
Insulin signaling
C
Parathyroid hormone (PTH) signaling
D
Epidermal growth factor (EGF) signaling
Verified step by step guidance
1
Understand the concept of bone remodeling: Bone remodeling is a continuous process where old bone tissue is replaced by new bone tissue. It is regulated by various hormones and signaling pathways to maintain bone strength and calcium homeostasis.
Review the role of calcitonin signaling: Calcitonin is a hormone that helps regulate calcium levels in the blood by inhibiting osteoclast activity, which reduces bone resorption. This directly impacts bone remodeling.
Examine the role of insulin signaling: Insulin plays a role in bone metabolism by influencing osteoblast activity, which is responsible for bone formation. Therefore, insulin signaling can affect bone remodeling.
Analyze the role of parathyroid hormone (PTH) signaling: PTH is a key regulator of calcium homeostasis and bone remodeling. It stimulates osteoclast activity to increase calcium release from bones and also influences osteoblasts for bone formation.
Consider the role of epidermal growth factor (EGF) signaling: EGF primarily influences cell growth, proliferation, and differentiation in tissues like skin and epithelial cells. It is not directly involved in the regulation of bone remodeling, making it unlikely to affect this process.