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Multiple Choice
Which of the following would be associated with the action of steroids on cells?
A
Binding to intracellular receptors and regulating gene expression
B
Opening of ligand-gated ion channels
C
Initiation of second messenger cascades via receptor tyrosine kinases
D
Activation of G protein-coupled receptors on the cell membrane
Verified step by step guidance
1
Understand the nature of steroids: Steroids are lipid-soluble molecules, which means they can easily pass through the lipid bilayer of the cell membrane. This property is key to their mechanism of action.
Recognize the type of receptor steroids interact with: Since steroids are lipid-soluble, they typically bind to intracellular receptors located in the cytoplasm or nucleus, rather than membrane-bound receptors.
Understand the role of steroid-receptor complexes: Once a steroid binds to its intracellular receptor, the complex often acts as a transcription factor, directly influencing gene expression by binding to specific DNA sequences.
Eliminate incorrect options: Opening of ligand-gated ion channels, initiation of second messenger cascades via receptor tyrosine kinases, and activation of G protein-coupled receptors are mechanisms associated with hydrophilic signaling molecules that cannot cross the cell membrane, unlike steroids.
Conclude the correct answer: The action of steroids is associated with binding to intracellular receptors and regulating gene expression, as this aligns with their lipid-soluble nature and mechanism of action.