Multiple Choice
Which of the following best describes the role of a ligand in cell signaling pathways?
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10. Cell Signaling
Introduction to Cell Signaling
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Which molecules typically bind to receptors that possess intracellular tyrosine kinase domains?
A
Growth factors such as epidermal growth factor (EGF)
B
Neurotransmitters such as acetylcholine
C
Cyclic AMP (cAMP)
D
Steroid hormones such as cortisol
Verified step by step guidance1
Understand the role of receptors with intracellular tyrosine kinase domains: These receptors are typically involved in signal transduction pathways and are activated by specific ligands, leading to phosphorylation of tyrosine residues on themselves or other proteins.
Recall the types of molecules that commonly bind to these receptors: Growth factors, such as epidermal growth factor (EGF), are well-known ligands for receptors with intracellular tyrosine kinase domains. These molecules initiate signaling cascades that regulate cell growth, division, and differentiation.
Eliminate neurotransmitters such as acetylcholine: Neurotransmitters typically bind to ion channel receptors or G-protein-coupled receptors, not tyrosine kinase receptors.
Eliminate cyclic AMP (cAMP): cAMP is a secondary messenger, not a ligand. It functions downstream in signaling pathways rather than binding directly to receptors.
Eliminate steroid hormones such as cortisol: Steroid hormones bind to intracellular receptors that act as transcription factors, not to receptors with tyrosine kinase domains.
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