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Multiple Choice
Which of the following mutations would likely be most dangerous to a cell?
A
A point mutation
B
A frameshift mutation
C
A missense mutation
D
A silent mutation
Verified step by step guidance
1
Understand the types of mutations: A point mutation involves a change in a single nucleotide base pair in DNA. A missense mutation results in a different amino acid being incorporated into a protein. A silent mutation does not change the amino acid sequence of a protein. A frameshift mutation involves the insertion or deletion of a nucleotide, which shifts the reading frame of the genetic code.
Consider the impact of each mutation on protein synthesis: A silent mutation typically has no effect on the protein. A missense mutation may alter the protein's function, but the change might not be drastic. A point mutation can have varying effects depending on its location and the resulting amino acid change.
Analyze the frameshift mutation: This type of mutation alters the reading frame of the genetic code, potentially changing every amino acid downstream of the mutation. This can lead to a completely nonfunctional protein or premature stop codons.
Evaluate the potential consequences: Frameshift mutations often result in more severe consequences for the cell because they can disrupt the entire protein structure and function, leading to loss of function or harmful gain of function.
Conclude which mutation is most dangerous: Given the potential for widespread disruption in protein synthesis, a frameshift mutation is likely the most dangerous to a cell compared to the other types of mutations listed.