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Multiple Choice
In mitochondrial electron transport, what is the direct role of $\mathrm{O_2}$?
A
It pumps protons across the inner mitochondrial membrane.
B
It directly synthesizes ATP from ADP and phosphate.
C
It acts as the final electron acceptor, forming water.
D
It donates electrons to Complex I.
Verified step by step guidance
1
Understand the context of mitochondrial electron transport: This process occurs in the inner mitochondrial membrane and is part of cellular respiration. It involves a series of protein complexes (I, II, III, IV) and mobile electron carriers that transfer electrons derived from nutrients.
Identify the role of oxygen ($\mathrm{O_2}$): Oxygen is involved in the final step of the electron transport chain, specifically at Complex IV (cytochrome c oxidase). It acts as the terminal electron acceptor.
Explain the mechanism: At Complex IV, electrons are transferred to oxygen ($\mathrm{O_2}$), which combines with protons ($\mathrm{H^+}$) to form water ($\mathrm{H_2O}$). This reaction is crucial for maintaining the flow of electrons through the chain.
Clarify why oxygen does not perform other roles: Oxygen does not pump protons across the membrane (this is done by Complexes I, III, and IV), nor does it directly synthesize ATP (ATP synthesis is carried out by ATP synthase, driven by the proton gradient). Oxygen also does not donate electrons to Complex I; instead, electron donors like NADH and FADH2 provide electrons to the chain.
Summarize the correct answer: Oxygen ($\mathrm{O_2}$) acts as the final electron acceptor in the electron transport chain, enabling the formation of water ($\mathrm{H_2O}$) and ensuring the continuation of electron flow, which is essential for ATP production.