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Multiple Choice
Which of the following factors play a role in shifting the oxygen–hemoglobin dissociation curve?
A
Amount of dietary fiber
B
Partial pressure of carbon dioxide (\(\mathrm{P_{CO_2}}\))
C
Concentration of plasma glucose
D
Presence of vitamin D
Verified step by step guidance
1
Understand the oxygen–hemoglobin dissociation curve: This curve represents the relationship between the partial pressure of oxygen (
) and the percentage of hemoglobin saturated with oxygen. Factors that shift this curve affect oxygen binding and release.
Identify factors that influence the curve: The curve can shift to the right (reduced oxygen affinity) or left (increased oxygen affinity) due to physiological changes. Key factors include partial pressure of carbon dioxide (
), pH, temperature, and levels of 2,3-bisphosphoglycerate (BPG).
Analyze the given options: Evaluate each factor listed in the problem. Dietary fiber and plasma glucose concentration do not directly affect the oxygen–hemoglobin dissociation curve. Vitamin D is also unrelated to this curve.
Focus on
: Increased
leads to a rightward shift of the curve (Bohr effect), reducing hemoglobin's affinity for oxygen and facilitating oxygen release to tissues.
Conclude the reasoning: The correct factor influencing the oxygen–hemoglobin dissociation curve is the partial pressure of carbon dioxide (
), as it directly impacts hemoglobin's oxygen-binding properties.