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Multiple Choice
Which of the following is a characteristic of cancer cells, such as HeLa cells, that helps them evade cell death?
A
They often have mutations that inactivate tumor suppressor genes like p53.
B
They have a reduced rate of cell division compared to normal cells.
C
They are more sensitive to signals that trigger apoptosis.
D
They lack the ability to repair DNA damage.
Verified step by step guidance
1
Understand the context: Cancer cells, such as HeLa cells, are known for their ability to evade normal cellular controls, including mechanisms that regulate cell death (apoptosis). This question is asking about a specific characteristic that allows them to avoid cell death.
Review the role of tumor suppressor genes: Tumor suppressor genes, like p53, are crucial for regulating the cell cycle and initiating apoptosis in response to DNA damage or other cellular stress. Mutations that inactivate these genes can allow cancer cells to bypass these controls.
Analyze the options: Evaluate each option to determine whether it aligns with the known characteristics of cancer cells. For example, consider whether cancer cells typically have a reduced rate of cell division, are more sensitive to apoptosis signals, or lack DNA repair mechanisms.
Focus on the correct characteristic: Cancer cells often have mutations in tumor suppressor genes like p53, which prevent the normal activation of apoptosis. This allows them to survive and proliferate despite signals that would normally trigger cell death in healthy cells.
Conclude the reasoning: Based on the analysis, the characteristic that helps cancer cells evade cell death is their mutations that inactivate tumor suppressor genes like p53. This is a hallmark of cancer biology and contributes to their unchecked growth and survival.