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Multiple Choice
In which phase of mitosis do sister chromatids separate?
A
Prophase
B
Telophase
C
Metaphase
D
Anaphase
Verified step by step guidance
1
Begin by understanding the process of mitosis, which is the division of a single cell into two genetically identical daughter cells. Mitosis consists of several phases: prophase, metaphase, anaphase, and telophase.
Recall that during prophase, the chromatin condenses into visible chromosomes, and the mitotic spindle begins to form. The nuclear envelope breaks down, but sister chromatids are still paired together.
In metaphase, the chromosomes align at the metaphase plate, which is the equatorial plane of the cell. The sister chromatids are still attached at the centromere, awaiting separation.
Anaphase is the phase where the sister chromatids are pulled apart. The centromeres split, and the spindle fibers shorten, pulling the chromatids toward opposite poles of the cell.
Finally, in telophase, the separated chromatids reach the poles, and the nuclear envelope re-forms around each set of chromosomes, completing the process of mitosis.