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Multiple Choice
Most carbon dioxide is carried from the body tissues to the lungs _____.
A
as bicarbonate ions ($\mathrm{HCO_3^-}$) dissolved in plasma
B
dissolved directly as CO$_2$ gas in plasma
C
bound to hemoglobin as carbaminohemoglobin
D
attached to oxygen molecules in red blood cells
Verified step by step guidance
1
Understand the context: Carbon dioxide (CO$_2$) is a waste product of cellular respiration and must be transported from body tissues to the lungs for exhalation. The question asks about the primary method of CO$_2$ transport in the blood.
Recall the three main ways CO$_2$ is transported in the blood: (1) as bicarbonate ions ($\mathrm{HCO_3^-}$) dissolved in plasma, (2) bound to hemoglobin as carbaminohemoglobin, and (3) dissolved directly as CO$_2$ gas in plasma.
Focus on the most common method: The majority of CO$_2$ is converted into bicarbonate ions ($\mathrm{HCO_3^-}$) through a reaction catalyzed by the enzyme carbonic anhydrase. This reaction occurs in red blood cells and can be represented as: \[ \mathrm{CO_2 + H_2O \leftrightarrow H_2CO_3 \leftrightarrow H^+ + HCO_3^-} \]
Understand the role of plasma: Once bicarbonate ions are formed, they are transported in the plasma. This is the primary method of CO$_2$ transport, accounting for about 70% of the total CO$_2$ carried in the blood.
Review the other options: (1) CO$_2$ bound to hemoglobin as carbaminohemoglobin accounts for about 20-23% of CO$_2$ transport. (2) CO$_2$ dissolved directly in plasma as a gas accounts for only about 7-10%. (3) CO$_2$ is not attached to oxygen molecules in red blood cells, so this option is incorrect.