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Multiple Choice
In which phase of mitosis do spindle microtubules attach to kinetochores?
A
Anaphase
B
Prometaphase
C
Metaphase
D
Telophase
Verified step by step guidance
1
Understand the role of spindle microtubules and kinetochores in mitosis: Spindle microtubules are structures that help separate chromosomes during cell division. Kinetochores are protein complexes located at the centromere of each chromosome, serving as attachment points for spindle microtubules.
Review the phases of mitosis: Mitosis consists of several phases—prophase, prometaphase, metaphase, anaphase, and telophase. Each phase has distinct events related to chromosome alignment and separation.
Focus on prometaphase: During prometaphase, the nuclear envelope breaks down, allowing spindle microtubules to access the chromosomes. This is the phase where spindle microtubules attach to the kinetochores.
Compare prometaphase with other phases: In metaphase, chromosomes are aligned at the metaphase plate, but the attachment of spindle microtubules to kinetochores has already occurred in prometaphase. Anaphase involves the separation of sister chromatids, and telophase is the final phase where the cell prepares to divide.
Conclude that the correct phase for spindle microtubules attaching to kinetochores is prometaphase, based on the sequence of events in mitosis.