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Multiple Choice
Which statement is true for the leading strand in DNA replication?
A
It is synthesized continuously in the 5' to 3' direction.
B
It requires multiple RNA primers for synthesis.
C
It is synthesized discontinuously in short fragments.
D
It is synthesized in the 3' to 5' direction.
Verified step by step guidance
1
Understand the process of DNA replication: DNA replication is the process by which a DNA molecule is copied to produce two identical DNA molecules. It occurs in the S phase of the cell cycle.
Identify the direction of synthesis: DNA polymerase, the enzyme responsible for adding nucleotides, can only add nucleotides to the 3' end of a DNA strand, meaning DNA synthesis occurs in the 5' to 3' direction.
Differentiate between leading and lagging strands: During replication, the two strands of DNA are separated, and each serves as a template for the new strand. The leading strand is synthesized continuously, while the lagging strand is synthesized in short fragments called Okazaki fragments.
Clarify the role of RNA primers: RNA primers are short sequences of RNA that provide a starting point for DNA synthesis. The leading strand requires only one RNA primer at the origin of replication, while the lagging strand requires multiple primers for each Okazaki fragment.
Conclude with the correct statement: The leading strand is synthesized continuously in the 5' to 3' direction, requiring only a single RNA primer at the start of replication.