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Multiple Choice
In the context of meiosis, what is nondisjunction?
A
The failure of homologous chromosomes or sister chromatids to separate properly during cell division
B
The pairing of homologous chromosomes during metaphase I
C
The exchange of genetic material between non-sister chromatids during prophase I
D
The formation of the spindle apparatus during prophase II
Verified step by step guidance
1
Understand the context of meiosis: Meiosis is a type of cell division that reduces the chromosome number by half, creating four haploid cells, each genetically distinct from the parent cell. It consists of two stages: Meiosis I and Meiosis II.
Define nondisjunction: Nondisjunction is an error in cell division where homologous chromosomes or sister chromatids fail to separate properly. This can occur during either Meiosis I or Meiosis II.
Identify when nondisjunction can occur: In Meiosis I, nondisjunction occurs if homologous chromosomes do not separate during anaphase I. In Meiosis II, it occurs if sister chromatids do not separate during anaphase II.
Consider the consequences of nondisjunction: This failure to separate can lead to gametes with an abnormal number of chromosomes, which can result in disorders such as Down syndrome, Turner syndrome, or Klinefelter syndrome.
Differentiate nondisjunction from other processes: Ensure you understand that nondisjunction is distinct from other meiotic processes such as the pairing of homologous chromosomes during metaphase I, crossing over during prophase I, and spindle formation during prophase II.