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Multiple Choice
Which of the following is most directly responsible for the falling (repolarizing) phase of the action potential in a neuron?
A
Opening of voltage-gated Na$^+$ channels
B
Activation of the Na$^+$/K$^+$ ATPase pump
C
Opening of voltage-gated K$^+$ channels
D
Closing of voltage-gated K$^+$ channels
Verified step by step guidance
1
Understand the concept of an action potential: An action potential is a rapid change in the electrical charge across a neuron's membrane, allowing the neuron to transmit signals. It consists of depolarization (rising phase) and repolarization (falling phase).
Recognize the role of ion channels: During the action potential, specific ion channels open and close to allow the movement of ions (Na$^+$ and K$^+$) across the membrane, which changes the membrane potential.
Focus on the repolarizing phase: The falling phase of the action potential occurs when the membrane potential returns to its resting state after depolarization. This is primarily due to the movement of K$^+$ ions out of the cell.
Identify the mechanism responsible for repolarization: The opening of voltage-gated K$^+$ channels allows K$^+$ ions to flow out of the neuron, driven by their concentration gradient. This outward movement of positive ions reduces the positive charge inside the cell, leading to repolarization.
Clarify why other options are incorrect: The opening of voltage-gated Na$^+$ channels is responsible for depolarization, not repolarization. The Na$^+$/K$^+$ ATPase pump helps maintain ion gradients over time but is not directly responsible for the rapid repolarization phase. Closing of voltage-gated K$^+$ channels would prevent repolarization rather than cause it.