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Multiple Choice
Which of the following is an example of an excitatory postsynaptic potential (EPSP) in a typical neuron?
A
Inhibition of voltage-gated Ca$^{2+}$ channels at the presynaptic terminal
B
Opening of ligand-gated Cl$^-$ channels causing membrane hyperpolarization
C
Activation of voltage-gated K$^+$ channels leading to repolarization
D
Opening of ligand-gated Na$^+$ channels causing membrane depolarization
Verified step by step guidance
1
Step 1: Understand the concept of an excitatory postsynaptic potential (EPSP). EPSPs are changes in the membrane potential of a postsynaptic neuron that make it more likely to fire an action potential. This typically involves depolarization, where the inside of the neuron becomes less negative.
Step 2: Analyze the options provided. For an EPSP to occur, ions that cause depolarization must flow into the neuron. Sodium ions (Na$^+$) are commonly involved in depolarization because their influx makes the membrane potential less negative.
Step 3: Evaluate the first option: 'Inhibition of voltage-gated Ca$^{2+}$ channels at the presynaptic terminal.' This does not directly cause depolarization in the postsynaptic neuron, so it is not an EPSP.
Step 4: Evaluate the second option: 'Opening of ligand-gated Cl$^-$ channels causing membrane hyperpolarization.' Hyperpolarization makes the membrane potential more negative, which is inhibitory rather than excitatory, so this is not an EPSP.
Step 5: Evaluate the fourth option: 'Opening of ligand-gated Na$^+$ channels causing membrane depolarization.' The influx of Na$^+$ ions reduces the negativity of the membrane potential, leading to depolarization, which is characteristic of an EPSP. This is the correct answer.