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Multiple Choice
All of the following are true regarding natural killer (NK) cells EXCEPT:
A
They require prior exposure to a specific antigen to function.
B
They are part of the innate immune system.
C
They release perforin and granzymes to destroy target cells.
D
They can induce apoptosis in virus-infected cells.
Verified step by step guidance
1
Step 1: Begin by understanding the role of natural killer (NK) cells in the immune system. NK cells are a type of lymphocyte that play a critical role in the innate immune system, which is the body's first line of defense against pathogens.
Step 2: Recall that NK cells do not require prior exposure to a specific antigen to function. This is a key feature that distinguishes them from adaptive immune cells like T cells and B cells, which do require antigen-specific activation.
Step 3: Understand the mechanisms NK cells use to destroy target cells. NK cells release perforin, which forms pores in the target cell membrane, and granzymes, which enter the cell through these pores to induce apoptosis (programmed cell death).
Step 4: Recognize that NK cells are effective against virus-infected cells and tumor cells. They identify these abnormal cells by detecting changes in surface molecules, such as reduced expression of MHC class I molecules.
Step 5: To answer the question, identify the statement that is incorrect based on the characteristics of NK cells. The incorrect statement is: 'They require prior exposure to a specific antigen to function,' as NK cells are part of the innate immune system and do not rely on antigen-specific activation.