Which of the following provides evidence from developmental biology of a shared evolutionary history?

Some stickleback fish develop protective spines, and other stickleback fish are spineless. Spine development is controlled by the expression of a gene known as Pitx1. The spineless phenotype is due to a mutation in Pitx1 that results in no expression of Pitx1 during development in regions where spines would otherwise form. When scientists compared the Pitx1 coding sequence in spined and spineless fish, they found this sequence was the same in both types of fish. Propose plausible hypotheses for the location of this mutation and for how it alters spine development.

Some humans have genes that make them resistant to infection by HIV. Would human populations likely evolve differently in areas of the world where HIV infection rates are high? Explain your logic.

Type I diabetes is a form of diabetes that is due to the loss of insulin-producing cells of the pancreas. The potential of stem cells—in particular, induced pluripotent stem (iPS) cells—for therapy has gotten a lot of press.

What are iPS cells?

a. Cells taken from early human embryos

b. Cells taken from the pancreas of people without diabetes

c. Cells derived by de-differentiating specialized adult cells

d. Cells derived by differentiating pancreas precursor cells

Type I diabetes is a form of diabetes that is due to the loss of insulin-producing cells of the pancreas. The potential of stem cells—in particular, induced pluripotent stem (iPS) cells—for therapy has gotten a lot of press.

If researchers were attempting to stimulate the differentiation of iPS cells, which of the following would they most likely add to the cell-culture medium (the liquid surrounding the cells)?

a. Activin A, an extracellular signal protein

b. Sox-2, a transcription factor active in early development

c. Grb-2, an intracellular signal transduction protein

d. Lactase, an enzyme that catalyzes the breakdown of lactose