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Multiple Choice
Which of the following explains why sickle-cell disease continues to persist in Africa?
A
Sickle-cell disease is a new mutation that has recently appeared in Africa.
B
Sickle-cell disease is caused by a virus that is prevalent in Africa.
C
Sickle-cell disease is a result of poor healthcare systems in Africa.
D
Sickle-cell disease provides a survival advantage against malaria.
Verified step by step guidance
1
Understand the genetic basis of sickle-cell disease: It is caused by a mutation in the hemoglobin gene, leading to the production of abnormal hemoglobin known as hemoglobin S.
Recognize the relationship between sickle-cell disease and malaria: Individuals who are heterozygous for the sickle-cell trait (carrying one normal hemoglobin gene and one sickle-cell gene) have a survival advantage in regions where malaria is prevalent.
Explain the mechanism of this advantage: The presence of hemoglobin S in red blood cells can interfere with the lifecycle of the malaria parasite, reducing the severity of the infection.
Consider the evolutionary perspective: In areas where malaria is common, the sickle-cell trait is naturally selected because it increases the likelihood of survival and reproduction, thus maintaining the presence of the trait in the population.
Conclude with the persistence of sickle-cell disease: Despite its health challenges, the sickle-cell trait continues to be prevalent in Africa due to its protective effect against malaria, illustrating a case of balanced polymorphism.