What steps are required for most B cells to become fully activated and differentiate into plasma cells?
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41. Immune System
Adaptive Immunity
Problem 9
Textbook Question
In the condition myasthenia gravis, antibodies bind to and block certain receptors on muscle cells, preventing muscle contraction. This condition is best classified as an
a. Immunodeficiency disorder.
b. Exaggerated immune reaction.
c. Allergic reaction.
d. Autoimmune disorder.

1
Understand the condition described: Myasthenia gravis is a condition where antibodies target and block receptors on muscle cells, interfering with normal muscle contraction.
Recall the definition of an autoimmune disorder: It occurs when the immune system mistakenly attacks the body's own cells, tissues, or organs.
Compare the condition to other immune-related disorders: Immunodeficiency disorders involve a weakened immune system, exaggerated immune reactions involve an overactive response to external threats, and allergic reactions are hypersensitive responses to harmless substances.
Identify the key feature of myasthenia gravis: The immune system produces antibodies that attack the body's own muscle cell receptors, which aligns with the definition of an autoimmune disorder.
Conclude that the condition is best classified as an autoimmune disorder based on the mechanism of action described.

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Key Concepts
Here are the essential concepts you must grasp in order to answer the question correctly.
Autoimmune Disorder
An autoimmune disorder occurs when the immune system mistakenly attacks the body's own cells, tissues, or organs. In the case of myasthenia gravis, the immune system produces antibodies that target acetylcholine receptors on muscle cells, disrupting normal communication between nerves and muscles, leading to muscle weakness.
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Antibodies
Antibodies are specialized proteins produced by the immune system to identify and neutralize foreign objects like bacteria and viruses. In autoimmune disorders, these antibodies can mistakenly target the body's own cells, as seen in myasthenia gravis, where they block receptors essential for muscle contraction.
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Primary and Secondary Immunity
Neuromuscular Junction
The neuromuscular junction is the synapse or connection point between a motor neuron and a muscle fiber. It is crucial for muscle contraction, as the release of neurotransmitters at this junction stimulates muscle fibers. In myasthenia gravis, the blockage of receptors at this junction impairs muscle contraction, leading to the characteristic symptoms of the disorder.
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Motor Unit and Neuromuscular Junction
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