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Ch. 16 Microbial Life: Prokaryotes and Protists
Taylor - Campbell Biology: Concepts & Connections 10th Edition
Taylor, Simon, Dickey, Hogan10th EditionCampbell Biology: Concepts & ConnectionsISBN: 9780136538783Not the one you use?Change textbook
Chapter 16, Problem 12

Which of the following experiments could test the hypothesis that bacteria cause ulcers in humans? (Assume each experiment includes a control group.) Explain what evidence would be provided by the results of the experiment.
a. Identify the microbes found in the stomachs of ulcer patients.
b. Treat a group of ulcer patients with antibiotics.
c. Place a group of ulcer patients on a strict low-acid diet.
d. Obtain stomach fluid from ulcer patents and feed it to mice.

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Step 1: Understand the hypothesis. The hypothesis is that bacteria cause ulcers in humans. To test this, experiments should aim to establish a causal relationship between bacteria and the development or treatment of ulcers.
Step 2: Evaluate option a. Identifying microbes in the stomachs of ulcer patients can provide correlation but not causation. This experiment would show which microbes are present but would not confirm that bacteria cause ulcers.
Step 3: Evaluate option b. Treating ulcer patients with antibiotics targets bacteria. If the ulcers improve or heal after antibiotic treatment, this would provide evidence supporting the hypothesis that bacteria are involved in causing ulcers.
Step 4: Evaluate option c. Placing patients on a low-acid diet tests whether acid levels, not bacteria, are responsible for ulcers. This experiment does not directly test the bacterial hypothesis but could help rule out other factors.
Step 5: Evaluate option d. Feeding stomach fluid from ulcer patients to mice could test whether bacteria in the fluid cause ulcers in the mice. If the mice develop ulcers, this would provide strong evidence supporting the hypothesis that bacteria are the cause.

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Key Concepts

Here are the essential concepts you must grasp in order to answer the question correctly.

Hypothesis Testing

Hypothesis testing is a scientific method used to determine the validity of a proposed explanation for a phenomenon. In this context, the hypothesis suggests that bacteria are the causative agents of ulcers. To test this, experiments must be designed to either support or refute this hypothesis, often involving control groups to ensure that results are due to the variable being tested.
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Control Groups

Control groups are essential in experimental design as they provide a baseline for comparison against the experimental group. In the context of testing the hypothesis about bacteria and ulcers, a control group might consist of ulcer patients who do not receive the experimental treatment, allowing researchers to observe the effects of the treatment and determine if any changes are due to the bacteria or other factors.
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Causation vs. Correlation

Understanding the difference between causation and correlation is crucial in interpreting experimental results. Just because two variables appear to be related does not mean one causes the other. In the case of bacteria and ulcers, experiments must be designed to establish a causal link, such as demonstrating that the presence of specific bacteria leads to ulcer formation, rather than merely observing that they occur together.
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