Multiple Choice
Which MHC class presents intracellular pathogens?
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21. The Immune System
MHC and Antigen Presentation
Multiple Choice
In the context of MHC and antigen presentation, where are MHC molecules primarily located on a cell?
A
Exclusively within the nucleus where they regulate transcription of immune genes
B
Free-floating in the cytosol where they bind peptides before secretion
C
Stored only in lysosomes and never displayed at the cell surface
D
Embedded in the plasma membrane with their peptide-binding domains exposed on the extracellular surface
Verified step by step guidance1
Understand the role of MHC (Major Histocompatibility Complex) molecules in antigen presentation, which is to display peptide fragments to T cells for immune recognition.
Recall that MHC molecules must be accessible to T cells, which interact with the extracellular environment, so their location should allow peptide display outside the cell.
Recognize that MHC molecules are transmembrane proteins embedded in the plasma membrane, with their peptide-binding domains exposed on the extracellular surface to present antigens to T cells.
Eliminate incorrect options: MHC molecules are not located exclusively in the nucleus, nor are they free-floating in the cytosol or stored only in lysosomes without surface expression.
Conclude that the primary location of MHC molecules is embedded in the plasma membrane, enabling them to present antigenic peptides to the immune system effectively.
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