Multiple Choice
Which MHC class presents intracellular pathogens?
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21. The Immune System
MHC and Antigen Presentation
Multiple Choice
In the context of MHC-mediated antigen presentation, which of the following is NOT considered a professional antigen-presenting cell (APC)?
A
Macrophage
B
Dendritic cell
C
B lymphocyte
D
Neutrophil
Verified step by step guidance1
Step 1: Understand the role of professional antigen-presenting cells (APCs). Professional APCs are cells that can process and present antigens via Major Histocompatibility Complex (MHC) molecules to T cells, initiating an adaptive immune response.
Step 2: Identify the common professional APCs. These typically include macrophages, dendritic cells, and B lymphocytes, all of which have the ability to present antigens effectively to T cells.
Step 3: Review the function of neutrophils. Neutrophils are primarily involved in innate immunity and act as first responders to infection, mainly through phagocytosis and release of antimicrobial substances, but they do not typically present antigens via MHC to T cells.
Step 4: Compare the listed cells to determine which one does not fit the professional APC category. Since macrophages, dendritic cells, and B lymphocytes are professional APCs, the neutrophil stands out as the cell that is NOT considered a professional APC.
Step 5: Conclude that neutrophils, despite their important role in immune defense, are not professional antigen-presenting cells because they lack the specialized antigen presentation function characteristic of macrophages, dendritic cells, and B lymphocytes.
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