Multiple Choice
Which of the following is not a type of DNA damage repair?
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16. Cell Division
DNA Repair and Recombination
Multiple Choice
In the context of DNA repair and recombination, which cellular component is most directly damaged by UV radiation, creating lesions such as cyclobutane pyrimidine dimers?
A
Nuclear DNA (the genome), where UV induces pyrimidine dimers that distort the DNA helix
B
Microtubule proteins in the cytoskeleton, which undergo UV-triggered double-strand breaks
C
Ribosomal RNA in the nucleolus, which is primarily cleaved into fragments by UV exposure
D
Plasma membrane phospholipids, which are the main targets of UV-induced base modifications
Verified step by step guidance1
Understand that UV radiation primarily affects molecules that absorb UV light strongly, such as nucleic acids and proteins.
Recall that UV radiation causes specific types of DNA damage, notably the formation of cyclobutane pyrimidine dimers, which are covalent linkages between adjacent pyrimidine bases (usually thymine or cytosine) in DNA.
Recognize that these pyrimidine dimers distort the DNA double helix, interfering with normal base pairing and DNA replication.
Identify that this damage occurs in nuclear DNA (the genome), as it contains the pyrimidine bases susceptible to dimer formation.
Conclude that other cellular components like microtubule proteins, ribosomal RNA, or plasma membrane phospholipids are not the primary targets of UV-induced pyrimidine dimer lesions.
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