Table of contents

1. Introduction to Genetics51m
2. Mendel's Laws of Inheritance3h 37m
3. Extensions to Mendelian Inheritance2h 41m
4. Genetic Mapping and Linkage2h 28m
5. Genetics of Bacteria and Viruses1h 21m
6. Chromosomal Variation1h 48m
7. DNA and Chromosome Structure56m
8. DNA Replication1h 10m
9. Mitosis and Meiosis1h 34m
10. Transcription1h 0m
11. Translation58m
12. Gene Regulation in Prokaryotes1h 19m
13. Gene Regulation in Eukaryotes44m
14. Genetic Control of Development44m
15. Genomes and Genomics1h 50m
16. Transposable Elements47m
17. Mutation, Repair, and Recombination1h 6m
18. Molecular Genetic Tools19m
- Genetic Cloning
  9m
- Methods for Analyzing DNA
  9m
19. Cancer Genetics29m
- Overview of Cancer
  21m
- Cancer Mutations
  7m
20. Quantitative Genetics1h 26m
21. Population Genetics50m
- Hardy Weinberg
  19m
- Allelic Frequency Changes
  31m
22. Evolutionary Genetics29m

17. Mutation, Repair, and Recombination

Types of Mutations

Genetics

17. Mutation, Repair, and Recombination

Types of Mutations

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Multiple Choice

Which of the following types of mutations is usually considered most dangerous to the function of a protein?

Frameshift mutation

Synonymous mutation

Silent mutation

Missense mutation

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Verified step by step guidance

Step 1: Understand the types of mutations listed. A synonymous or silent mutation changes the DNA sequence without altering the amino acid sequence of the protein, so it usually has little to no effect on protein function.

Step 2: Recognize that a missense mutation changes one amino acid in the protein sequence, which can affect protein function depending on the importance of that amino acid in the protein's structure or activity.

Step 3: Learn that a frameshift mutation results from insertions or deletions of nucleotides that are not in multiples of three, causing a shift in the reading frame of the codons during translation.

Step 4: Understand that because frameshift mutations alter the entire downstream amino acid sequence, they often produce a completely nonfunctional protein or trigger premature stop codons, making them usually the most dangerous.

Step 5: Conclude that among the options, frameshift mutations are generally considered the most harmful to protein function due to their extensive impact on the amino acid sequence and protein structure.