Mothers will pass on a mitochondrial defect to their offspring. In a type of gene therapy, one approach to circumvent this problem is to have two different maternal contributions, with the nucleus of the female with the defective mitochondria being placed in an enucleated egg derived from a female with normal mitochondria. After fertilization, the resulting offspring would have three parental sources of DNA—with nuclear DNA derived from a mother and a father, and mitochondrial DNA derived from another 'mother.' Recently, children with this genetic makeup have been born, but the elimination of defective mitochondria is not complete, with the amount of defective mitochondria derived from the defective mother ranging from 0 to 9%. Discuss potential complications resulting from such a mixture of genomes.
Table of contents
- 1. Introduction to Genetics51m
- 2. Mendel's Laws of Inheritance3h 37m
- 3. Extensions to Mendelian Inheritance2h 41m
- 4. Genetic Mapping and Linkage2h 28m
- 5. Genetics of Bacteria and Viruses1h 21m
- 6. Chromosomal Variation1h 48m
- 7. DNA and Chromosome Structure56m
- 8. DNA Replication1h 10m
- 9. Mitosis and Meiosis1h 34m
- 10. Transcription1h 0m
- 11. Translation58m
- 12. Gene Regulation in Prokaryotes1h 19m
- 13. Gene Regulation in Eukaryotes44m
- 14. Genetic Control of Development44m
- 15. Genomes and Genomics1h 50m
- 16. Transposable Elements47m
- 17. Mutation, Repair, and Recombination1h 6m
- 18. Molecular Genetic Tools19m
- 19. Cancer Genetics29m
- 20. Quantitative Genetics1h 26m
- 21. Population Genetics50m
- 22. Evolutionary Genetics29m
3. Extensions to Mendelian Inheritance
Organelle DNA
Struggling with Genetics?
Join thousands of students who trust us to help them ace their exams!Watch the first videoMultiple Choice
Which type of DNA is typically found in most bacterial cells?
A
Single-stranded RNA
B
Circular double-stranded DNA
C
Linear double-stranded DNA
D
Circular single-stranded DNA

1
Understand the question is asking about the typical form of DNA found in most bacterial cells, focusing on the structure and type of their genetic material.
Recall that bacterial genomes are usually composed of DNA, not RNA, so single-stranded RNA can be excluded as a typical bacterial genetic material.
Consider the shape and strandedness of bacterial DNA: most bacteria have their DNA organized as a circular molecule rather than linear, and it is double-stranded rather than single-stranded.
Review that linear double-stranded DNA is more common in eukaryotic chromosomes, while circular double-stranded DNA is characteristic of bacterial chromosomes.
Conclude that the typical DNA found in most bacterial cells is circular double-stranded DNA, which allows for efficient replication and compact storage within the cell.
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