Multiple Choice
Which of the following statements best applies to the inactive X chromosome in mammalian females?
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3. Extensions to Mendelian Inheritance
X-Inactivation
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In the context of X-inactivation, where is heterochromatin not commonly located?
A
Barr body of the inactivated X chromosome
B
Telomeric regions of the inactivated X chromosome
C
Euchromatic regions of the active X chromosome
D
Pericentromeric regions of the inactivated X chromosome
Verified step by step guidance1
Understand that heterochromatin is a tightly packed form of DNA, which is generally transcriptionally inactive, while euchromatin is loosely packed and transcriptionally active.
Recall that X-inactivation involves the formation of a Barr body, which is the inactivated X chromosome condensed into heterochromatin.
Recognize that heterochromatin is commonly found in the Barr body, telomeric regions, and pericentromeric regions of the inactivated X chromosome because these areas are transcriptionally silent or structurally condensed.
Identify that euchromatic regions are characteristic of the active X chromosome, where genes are accessible and actively transcribed, so heterochromatin is not commonly located there.
Conclude that heterochromatin is not commonly found in the euchromatic regions of the active X chromosome, distinguishing it from the inactivated X chromosome regions.
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