Multiple Choice
Which type of mutation occurs only in reproductive cells (gametes) and can therefore be passed to offspring?
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17. Mutation, Repair, and Recombination
Types of Mutations
Multiple Choice
Which type of mutation always produces a stop codon in the coding sequence (thereby prematurely terminating translation)?
A
In-frame insertion (multiple of 3 nucleotides)
B
Nonsense mutation
C
Silent (synonymous) mutation
D
Missense mutation
Verified step by step guidance1
Understand the types of mutations listed: In-frame insertion, Silent mutation, Missense mutation, and Nonsense mutation.
Recall that a nonsense mutation is a point mutation in a DNA sequence that results in a premature stop codon within the coding sequence.
Recognize that a stop codon signals the termination of translation, causing the protein synthesis to end early, which can lead to a truncated and usually nonfunctional protein.
Contrast this with silent mutations, which do not change the amino acid sequence, and missense mutations, which change one amino acid but do not necessarily create a stop codon.
Note that in-frame insertions add nucleotides in multiples of three, preserving the reading frame and typically not causing premature stop codons.
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