Chromatin remodeling by the SWI/SNF complex requires hydrolysis of ATP. What purpose does this serve?
Table of contents
- 1. Introduction to Genetics51m
- 2. Mendel's Laws of Inheritance3h 37m
- 3. Extensions to Mendelian Inheritance2h 41m
- 4. Genetic Mapping and Linkage2h 28m
- 5. Genetics of Bacteria and Viruses1h 21m
- 6. Chromosomal Variation1h 48m
- 7. DNA and Chromosome Structure56m
- 8. DNA Replication1h 10m
- 9. Mitosis and Meiosis1h 34m
- 10. Transcription1h 0m
- 11. Translation58m
- 12. Gene Regulation in Prokaryotes1h 19m
- 13. Gene Regulation in Eukaryotes44m
- 14. Genetic Control of Development44m
- 15. Genomes and Genomics1h 50m
- 16. Transposable Elements47m
- 17. Mutation, Repair, and Recombination1h 6m
- 18. Molecular Genetic Tools19m
- 19. Cancer Genetics29m
- 20. Quantitative Genetics1h 26m
- 21. Population Genetics50m
- 22. Evolutionary Genetics29m
13. Gene Regulation in Eukaryotes
Epigenetics, Chromatin Modifications, and Regulation
Problem 12
Textbook Question
What are the different chromatin classifications, and what is their relationship to gene expression?

1
Understand that chromatin is the complex of DNA and proteins (mainly histones) that forms chromosomes within the nucleus of eukaryotic cells. Chromatin can be classified into two main types: euchromatin and heterochromatin.
Euchromatin is the less condensed form of chromatin. It is generally associated with active gene expression because the DNA is more accessible to transcription factors and RNA polymerase.
Heterochromatin is the more condensed form of chromatin. It is typically associated with gene silencing because the tightly packed structure makes the DNA less accessible to the transcriptional machinery.
Heterochromatin can be further divided into two subtypes: constitutive heterochromatin, which is always condensed and contains repetitive sequences (e.g., centromeres and telomeres), and facultative heterochromatin, which can switch between condensed and relaxed states depending on the cell's needs (e.g., the inactivated X chromosome in females).
The relationship between chromatin structure and gene expression is regulated by epigenetic modifications, such as DNA methylation and histone modifications. These modifications influence whether chromatin is in an open (euchromatin) or closed (heterochromatin) state, thereby controlling gene accessibility and expression.

This video solution was recommended by our tutors as helpful for the problem above
Video duration:
3mPlay a video:
Was this helpful?
Key Concepts
Here are the essential concepts you must grasp in order to answer the question correctly.
Chromatin Structure
Chromatin is a complex of DNA and proteins that forms chromosomes within the nucleus of eukaryotic cells. It exists in two primary forms: euchromatin, which is loosely packed and associated with active gene expression, and heterochromatin, which is tightly packed and generally transcriptionally inactive. The structure of chromatin plays a crucial role in regulating access to DNA for transcription and replication.
Recommended video:
Guided course
Chromatin
Gene Expression Regulation
Gene expression regulation refers to the mechanisms that control the transcription of genes, determining when and how much of a gene product is produced. This regulation can be influenced by chromatin structure, where modifications such as methylation and acetylation can either promote or inhibit access to the DNA, thereby affecting the expression of nearby genes. Understanding these regulatory mechanisms is essential for comprehending how genes are turned on or off in response to various signals.
Recommended video:
Guided course
Penetrance and Expressivity
Epigenetics
Epigenetics involves heritable changes in gene expression that do not involve alterations to the underlying DNA sequence. These changes can be influenced by environmental factors and can affect chromatin structure through chemical modifications. Epigenetic mechanisms, such as DNA methylation and histone modification, play a significant role in determining chromatin classifications and, consequently, the expression of genes, linking environmental influences to genetic outcomes.
Recommended video:
Guided course
Chromatin
Related Videos
Related Practice
Textbook Question
478
views