Multiple Choice
In the overview of DNA replication, what is the primary function of DNA polymerase?
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8. DNA Replication
Overview of DNA Replication
Multiple Choice
In the context of DNA replication, what is an RNA primer?
A
An enzyme that unwinds the DNA double helix ahead of the replication fork
B
A protein that stabilizes single-stranded DNA and prevents it from reannealing
C
A short RNA strand synthesized by primase that provides a free OH group for DNA polymerase to begin DNA synthesis
D
A short DNA fragment formed on the lagging strand that is later joined by DNA ligase
Verified step by step guidance1
Understand that during DNA replication, DNA polymerase cannot start synthesizing a new DNA strand from scratch; it requires a free 3\' OH group to add nucleotides.
Recognize that an RNA primer is a short strand of RNA synthesized by the enzyme primase, which provides this necessary free 3\' OH group.
Know that the RNA primer binds to the single-stranded DNA template, allowing DNA polymerase to extend the new DNA strand by adding nucleotides complementary to the template.
Differentiate the RNA primer from other components: it is not an enzyme, nor a protein that stabilizes DNA, nor a DNA fragment formed on the lagging strand (which are Okazaki fragments).
Summarize that the RNA primer is essential for initiating DNA synthesis because it supplies the starting point for DNA polymerase to begin replication.
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