Neurofibromatosis 1 (NF1) is an autosomal dominant disorder inherited on human chromosome 17. Part of the analysis mapping the NF1 gene to chromosome 17 came from genetic linkage studies testing segregation of NF1 and DNA genetic markers on various chromosomes. A DNA marker with two alleles, designated 1 and 2, is linked to NF1. The pedigree below shows segregation of NF1 (darkened symbols) and gives genotypes for the DNA marker for each family member.

Based on the phase of alleles on chromosomes in generation II, is there any evidence of recombination among the eight offspring in generation III? Explain.

Traditional gene mapping has been applied successfully to a variety of organisms including yeast, fungi, maize, and Drosophila. However, human gene mapping has only recently shared a similar spotlight. What factors have delayed the application of traditional gene-mapping techniques in humans?

In a certain plant, fruit is either red or yellow, and fruit shape is either oval or long. Red and oval are the dominant traits. Two plants, both heterozygous for these traits, were testcrossed, with the following results.

Determine the location of the genes relative to one another and the genotypes of the two parental plants.

Two plants in a cross were each heterozygous for two gene pairs (Ab/aB) whose loci are linked and 25 mu apart. Assuming that crossing over occurs during the formation of both male and female gametes and that the A and B alleles are dominant, determine the phenotypic ratio of their offspring.

Neurofibromatosis 1 (NF1) is an autosomal dominant disorder inherited on human chromosome 17. Part of the analysis mapping the NF1 gene to chromosome 17 came from genetic linkage studies testing segregation of NF1 and DNA genetic markers on various chromosomes. A DNA marker with two alleles, designated 1 and 2, is linked to NF1. The pedigree below shows segregation of NF1 (darkened symbols) and gives genotypes for the DNA marker for each family member.

What is the estimated recombination frequency between the NF1 gene and the DNA marker?

Neurofibromatosis 1 (NF1) is an autosomal dominant disorder inherited on human chromosome 17. Part of the analysis mapping the NF1 gene to chromosome 17 came from genetic linkage studies testing segregation of NF1 and DNA genetic markers on various chromosomes. A DNA marker with two alleles, designated 1 and 2, is linked to NF1. The pedigree below shows segregation of NF1 (darkened symbols) and gives genotypes for the DNA marker for each family member.

Determine the alleles for the NF1 gene and the DNA marker gene on each chromosome carried by the four family members in generation I and generation II. Use N for the dominant NF1 allele and n for the recessive allele and assume I-1 is heterozygous for the disease allele (Nn).

A number of human–mouse somatic cell hybrid clones were examined for the expression of specific human genes and the presence of human chromosomes. The results are summarized in the following table. Assign each gene to the chromosome on which it is located.

A 2006 genetic study of a large American family (Ikeda et al., 2006) identified genetic linkage between DNA markers on chromosome 11 and the gene producing the autosomal dominant neuromuscular disorder spinocerebellar ataxia type 5 (SCA5). The following lod score data are taken from the 2006 study:                  

Based on the available information, is DNA marker A linked to the gene producing SCA5? Explain your answer.

A 2006 genetic study of a large American family (Ikeda et al., 2006) identified genetic linkage between DNA markers on chromosome 11 and the gene producing the autosomal dominant neuromuscular disorder spinocerebellar ataxia type 5 (SCA5). The following lod score data are taken from the 2006 study:                  

What is the maximum value for each set of lod scores?