Multiple Choice
In the overview of DNA replication, which enzyme is primarily responsible for unwinding the parental DNA double helix at the replication fork?
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8. DNA Replication
Overview of DNA Replication
Multiple Choice
In the context of DNA replication, what is the main function of DNA polymerase?
A
To unwind the DNA double helix ahead of the replication fork by breaking hydrogen bonds between base pairs
B
To synthesize new DNA strands by adding nucleotides to the 3′ end of a growing DNA strand using a template strand
C
To join Okazaki fragments together by forming phosphodiester bonds between adjacent DNA fragments
D
To synthesize short RNA primers that provide a free 3′ hydroxyl group for DNA synthesis to begin
Verified step by step guidance1
Understand the role of DNA polymerase in DNA replication, which is to synthesize new DNA strands.
Recall that DNA polymerase adds nucleotides to the 3′ end of a growing DNA strand, using the existing strand as a template.
Differentiate DNA polymerase's function from other enzymes: helicase unwinds the DNA, ligase joins Okazaki fragments, and primase synthesizes RNA primers.
Recognize that DNA polymerase requires a free 3′ hydroxyl group to add nucleotides, which is provided by the RNA primer.
Summarize that the main function of DNA polymerase is to catalyze the formation of phosphodiester bonds between nucleotides, extending the DNA strand in the 5′ to 3′ direction.
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