Table of contents

1. Introduction to Genetics51m
2. Mendel's Laws of Inheritance3h 37m
3. Extensions to Mendelian Inheritance2h 41m
4. Genetic Mapping and Linkage2h 28m
5. Genetics of Bacteria and Viruses1h 21m
6. Chromosomal Variation1h 48m
7. DNA and Chromosome Structure56m
8. DNA Replication1h 10m
9. Mitosis and Meiosis1h 34m
10. Transcription1h 0m
11. Translation58m
12. Gene Regulation in Prokaryotes1h 19m
13. Gene Regulation in Eukaryotes44m
14. Genetic Control of Development44m
15. Genomes and Genomics1h 50m
16. Transposable Elements47m
17. Mutation, Repair, and Recombination1h 6m
18. Molecular Genetic Tools19m
- Genetic Cloning
  9m
- Methods for Analyzing DNA
  9m
19. Cancer Genetics29m
- Overview of Cancer
  21m
- Cancer Mutations
  7m
20. Quantitative Genetics1h 26m
21. Population Genetics50m
- Hardy Weinberg
  19m
- Allelic Frequency Changes
  31m
22. Evolutionary Genetics29m

21. Population Genetics

Allelic Frequency Changes

Genetics

21. Population Genetics

Allelic Frequency Changes

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1:26 minutes

Problem 33b

Textbook Question

Evaluate the following pedigree, and answer the questions below for individual IV-1. What is F for this individual?

Verified step by step guidance

Step 1: Understand the concept of 'F', which represents the inbreeding coefficient. It measures the probability that an individual has two alleles at a locus that are identical by descent due to shared ancestry.

Step 2: Analyze the pedigree provided. Identify all ancestors of individual IV-1 and determine if there are any loops in the pedigree (i.e., instances where the same ancestor appears more than once due to consanguineous mating).

Step 3: For each loop in the pedigree, calculate the contribution to the inbreeding coefficient using the formula:

F = Σ^{n} (1^{/ 2}) n^{+ 1}

, where n is the number of individuals in the loop excluding the individual being evaluated.

Step 4: Sum the contributions from all loops to determine the total inbreeding coefficient for individual IV-1. Ensure that you account for all possible paths of shared ancestry.

Step 5: Verify your calculations by cross-checking the pedigree and ensuring that all loops and shared ancestors have been accounted for correctly.

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Key Concepts

Here are the essential concepts you must grasp in order to answer the question correctly.

Pedigree Analysis

Pedigree analysis is a method used to study the inheritance patterns of traits in families. It involves creating a diagram that represents family relationships and the presence or absence of specific traits across generations. This visual representation helps in understanding how traits are passed down and can indicate whether a trait is dominant, recessive, or linked to sex chromosomes.

Coefficient of Inbreeding (F)

The coefficient of inbreeding (F) quantifies the probability that an individual has inherited identical alleles from both parents due to a common ancestor. It ranges from 0 (no inbreeding) to 1 (complete inbreeding). In pedigree analysis, calculating F helps assess the genetic diversity of a population and the potential for genetic disorders resulting from inbreeding.

Generational Relationships

Generational relationships in a pedigree chart indicate the lineage and connections between individuals. Each generation is typically represented by a horizontal row, with parents above their offspring. Understanding these relationships is crucial for determining the inheritance patterns of traits and calculating coefficients like F, as it allows for the identification of common ancestors and the degree of relatedness between individuals.

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